Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility
ABSTRACT Bacteria can adapt to stressful conditions through mutations affecting the RNA polymerase core subunits that lead to beneficial changes in transcription. In response to selection with rifampicin (RIF), mutations arise in the RIF resistance-determining region (RRDR) of rpoB that reduce antib...
Main Authors: | Yesha Patel, Vijay Soni, Kyu Y. Rhee, John D. Helmann |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2023-04-01
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Series: | mBio |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/mbio.03168-22 |
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