The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

The Alternative Complement Pathway Is Activated Without a Corresponding Terminal Pathway Activation in Patients With Heart Failure

ObjectiveDysregulation of the complement system has been described in patients with heart failure (HF). However, data on the alternative pathway are scarce and it is unknown if levels of factor B (FB) and the C3 convertase C3bBbP are elevated in these patients. We hypothesized that plasma levels of...

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Bibliographic Details
Main Authors: Margrethe Flesvig Holt, Annika E. Michelsen, Negar Shahini, Elisabeth Bjørkelund, Christina Holt Bendz, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Kaspar Broch, Thor Ueland, Lars Gullestad, Per H. Nilsson, Pål Aukrust, Tom Eirik Mollnes, Mieke C. Louwe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
heart failure
complement
alternative pathway
complement Factor B
C3bBbP
terminal complement complex
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.800978/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.800978/full

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