Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Abstract During hypoxic conditions, cells undergo critical adaptive responses that include the up-regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein response (UPR). While their induced signaling pathways have many distinct targets, there are some important conn...

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Bibliographic Details
Main Authors: Sylwia Bartoszewska, James F. Collawn
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:http://link.springer.com/article/10.1186/s11658-020-00212-1