4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin

4-Chloro-1,2-phenylenediamine induced structural perturbation and genotoxic aggregation in human serum albumin

4-Chloro-1,2-phenylenediamine (4-Cl-OPD) is a halogenated aromatic diamine used as a precursor in permanent hair color production. Despite its well-documented mutagenic and carcinogenic effects in various in vitro and in vivo models, its role in fibrillar aggregate formation and their genotoxic effe...

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Bibliographic Details
Main Authors: Mohd Sharib Warsi, Safia Habib, Mohd Talha, Shifa Khan, Priyam Singh, Abdul Rouf Mir, Minhal Abidi, Asif Ali, Moinuddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Chemistry
Subjects:
hair dyes toxicity
human serum albumin (HSA)
4-chloro-1,2-phenylenediamine
protein aggregation
genotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1016354/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1016354/full

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