The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer

Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control cellular adaptation to hypoxia and are considered promising therapeutic targets in IBD. However, their relevance in the pathogenesis of CAC...

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Bibliographic Details
Main Authors: Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-11-01
Series:JCI Insight
Subjects:
Inflammation
Oncology
Online Access:https://doi.org/10.1172/jci.insight.153337

Internet

https://doi.org/10.1172/jci.insight.153337

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