Hepatitis B Virus-Specific CD8+ T Cells Maintain Functional Exhaustion after Antigen Reexposure in an Acute Activation Immune Environment

Hepatitis B Virus-Specific CD8+ T Cells Maintain Functional Exhaustion after Antigen Reexposure in an Acute Activation Immune Environment

Chronic hepatitis B virus (HBV) infection is characterized by the presence of functionally exhausted HBV-specific CD8+ T cells. To characterize the possible residual effector ability of these cells, we reexposed CD8+ T cells from chronically HBV replicating mice to HBV antigens in an acute activatio...

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Bibliographic Details
Main Authors: Qin Wang, Wen Pan, Yanan Liu, Jinzhuo Luo, Dan Zhu, Yinping Lu, Xuemei Feng, Xuecheng Yang, Ulf Dittmer, Mengji Lu, Dongliang Yang, Jia Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
hepatitis B virus
CD8+ T cell
functional exhaustion
cell transfer
immune environment
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00219/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00219/full

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