Blood leukocyte LINE-1 hypomethylation and oxidative stress in knee osteoarthritis

Blood leukocyte LINE-1 hypomethylation and oxidative stress in knee osteoarthritis

Aim: Joints inflammation is one of the most pathologic processes leading to the development of osteoarthritis (OA), possibly leading to genomic instability. LINE-1 is transposable elements, and alterations in LINE-1 methylation induced by 8-hydroxy-2′-deoxyguanosine (8-OHdG) can cause genomic instab...

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Bibliographic Details
Main Authors: Nipaporn Teerawattanapong, Wanvisa Udomsinprasert, Srihatach Ngarmukos, Aree Tanavalee, Sittisak Honsawek
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Heliyon
Subjects:
Biochemistry
Molecular biology
LINE-1 methylation
Blood leukocytes
8-hydroxy-2′-deoxyguanosine
Knee osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844019327938

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http://www.sciencedirect.com/science/article/pii/S2405844019327938

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