TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection

TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection

The core of HIV-1 viruses bearing the capsid change N74D (HIV-1-N74D) do not bind the human protein CPSF6. In primary human CD4<sup>+</sup> T cells, HIV-1-N74D viruses exhibit an infectivity defect when compared to wild-type. We first investigated whether loss of CPSF6 binding accounts f...

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Bibliographic Details
Main Authors: Anastasia Selyutina, Lacy M. Simons, Karen A. Kirby, Angel Bulnes-Ramos, Pan Hu, Stefan G. Sarafianos, Judd F. Hultquist, Felipe Diaz-Griffero
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Viruses
Subjects:
HIV-1
N74D
CPSF6
TRIM5α<sub>hu</sub>
capsid
core
Online Access:https://www.mdpi.com/1999-4915/14/2/363

Internet

https://www.mdpi.com/1999-4915/14/2/363

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