Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption

Neuroprotective effect of Dl-3-n-butylphthalide against ischemia–reperfusion injury is mediated by ferroptosis regulation via the SLC7A11/GSH/GPX4 pathway and the attenuation of blood–brain barrier disruption

BackgroundStroke is one of the most severe diseases worldwide, resulting in physical and mental problems. Dl-3-n-butylphthalide, a compound derived from celery seed, has been approved for treating ischemic stroke in China. No study has evaluated how Dl-3-n-butylphthalide affects the ferroptosis SLC7...

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Bibliographic Details
Main Authors: Shuangli Xu, Xuewei Li, Yutian Li, Xiangling Li, E. Lv, Xiaojun Zhang, Youkui Shi, Yanqiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
N-butylphthalide
ischemic/reperfusion
ferroptosis
blood–brain barrier
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1028178/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2023.1028178/full

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