An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas
Strong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure compos...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19983-4 |
| _version_ | 1818735350515761152 |
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| author | Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock |
| author_facet | Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock |
| author_sort | Juliane Neupert |
| collection | DOAJ |
| description | Strong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure composed of deacetylated histones. |
| first_indexed | 2024-12-18T00:19:52Z |
| format | Article |
| id | doaj.art-a20d8d3521784cf38c6e1a4183cbef92 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:19:52Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a20d8d3521784cf38c6e1a4183cbef922022-12-21T21:27:22ZengNature PortfolioNature Communications2041-17232020-12-0111111710.1038/s41467-020-19983-4An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga ChlamydomonasJuliane Neupert0Sean D. Gallaher1Yinghong Lu2Daniela Strenkert3Na’ama Segal4Rouhollah Barahimipour5Sorel T. Fitz-Gibbon6Michael Schroda7Sabeeha S. Merchant8Ralph Bock9Max-Planck-Institut für Molekulare PflanzenphysiologieUniversity of California Los Angeles, Department of Chemistry and Biochemistry, and Institute for Genomics and ProteomicsMax-Planck-Institut für Molekulare PflanzenphysiologieMax-Planck-Institut für Molekulare PflanzenphysiologieMax-Planck-Institut für Molekulare PflanzenphysiologieMax-Planck-Institut für Molekulare PflanzenphysiologieUniversity of California Los Angeles, Department of Molecular, Cell and Developmental BiologyMax-Planck-Institut für Molekulare PflanzenphysiologieUniversity of California Los Angeles, Department of Chemistry and Biochemistry, and Institute for Genomics and ProteomicsMax-Planck-Institut für Molekulare PflanzenphysiologieStrong transgene suppression has been observed in Chlamydomonas reinhardtii, but the underlying mechanism is unknown. Here, the authors identify a sirtuin-type histone deacetylase that selectively acts on transgenic DNA to repress gene expression by assembling a repressive chromatin structure composed of deacetylated histones.https://doi.org/10.1038/s41467-020-19983-4 |
| spellingShingle | Juliane Neupert Sean D. Gallaher Yinghong Lu Daniela Strenkert Na’ama Segal Rouhollah Barahimipour Sorel T. Fitz-Gibbon Michael Schroda Sabeeha S. Merchant Ralph Bock An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas Nature Communications |
| title | An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_full | An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_fullStr | An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_full_unstemmed | An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_short | An epigenetic gene silencing pathway selectively acting on transgenic DNA in the green alga Chlamydomonas |
| title_sort | epigenetic gene silencing pathway selectively acting on transgenic dna in the green alga chlamydomonas |
| url | https://doi.org/10.1038/s41467-020-19983-4 |
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