Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a transmembrane domain. Some of the Siglecs (Sigl...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664619300968 |
| _version_ | 1818322693010751488 |
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| author | Chia-Hsueh Lin Ying-Chun Yeh Kuender D. Yang |
| author_facet | Chia-Hsueh Lin Ying-Chun Yeh Kuender D. Yang |
| author_sort | Chia-Hsueh Lin |
| collection | DOAJ |
| description | Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a transmembrane domain. Some of the Siglecs (Siglec-2–12, −17, -E, -F and -G) with three domains including immunoreceptor tyrosine-based inhibitory motif associated with Src homology 2 (SH2) tyrosine phosphatases (SHP1/2) usually deliver an inhibitory signal. Certain Siglecs (Siglec-14, -15, −16 and -H) containing no intracellular domain carry certain basic amino acid in transmembrane domain coupled with immunoreceptor tyrosine-based activating motif for cell activation. The number of Siglec-encoding genes has been correlated to lifespan of mammals, indicating its evolutional advantage on acquisition of Siglecs in humans. Certain polymorphisms of Siglecs have been associated with premature delivery, infection, schizophrenia, allergy, dementia or chronic obstructive pulmonary disease. Siglecs mainly expressing on leukocytes could interact with cis- or trans-SA ligands for cell–cell and host–organism interactions on infections, inflammations and cancers. Amplifying or eliminating the SA-Siglec interactions is a promising strategy to treat cancers, infections and inflammations, based on SA modifications in different linkages or nanoparticle decoration, and on the antibodies in conjugation of chimeric receptor design or toxins. |
| first_indexed | 2024-12-13T11:00:51Z |
| format | Article |
| id | doaj.art-a20fee17670e4895b7d2c2340a502203 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-13T11:00:51Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-a20fee17670e4895b7d2c2340a5022032022-12-21T23:49:15ZengElsevierJournal of the Formosan Medical Association0929-66462021-01-011201524Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancersChia-Hsueh Lin0Ying-Chun Yeh1Kuender D. Yang2Department of Medical Research, MacKay Memorial Hospital, Taipei, 10491, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, 10491, TaiwanDepartment of Medical Research, MacKay Memorial Hospital, Taipei, 10491, Taiwan; Mackay Children's Hospital, Taipei, Taiwan; Institute of Biomedical Sciences, Mackay Medical College, New Taipei City, 10491, Taiwan; Institute of Clinical Medicine, National Yang Ming University, Taipei, 11221, Taiwan; Institute of Microbiology & Immunology, National Defense Medical Center, Taipei, 11490, Taiwan; Corresponding author. Mackay Children's Hospital, No. 92, Sec. 2, Zhongshan North Road, Taipei, 10491, Taiwan.Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a transmembrane domain. Some of the Siglecs (Siglec-2–12, −17, -E, -F and -G) with three domains including immunoreceptor tyrosine-based inhibitory motif associated with Src homology 2 (SH2) tyrosine phosphatases (SHP1/2) usually deliver an inhibitory signal. Certain Siglecs (Siglec-14, -15, −16 and -H) containing no intracellular domain carry certain basic amino acid in transmembrane domain coupled with immunoreceptor tyrosine-based activating motif for cell activation. The number of Siglec-encoding genes has been correlated to lifespan of mammals, indicating its evolutional advantage on acquisition of Siglecs in humans. Certain polymorphisms of Siglecs have been associated with premature delivery, infection, schizophrenia, allergy, dementia or chronic obstructive pulmonary disease. Siglecs mainly expressing on leukocytes could interact with cis- or trans-SA ligands for cell–cell and host–organism interactions on infections, inflammations and cancers. Amplifying or eliminating the SA-Siglec interactions is a promising strategy to treat cancers, infections and inflammations, based on SA modifications in different linkages or nanoparticle decoration, and on the antibodies in conjugation of chimeric receptor design or toxins.http://www.sciencedirect.com/science/article/pii/S0929664619300968Sialic acid (SA)Sialic acid-binding immunoglobulin-like lectins (Siglecs)SA-Siglec axisSrc homology 2 tyrosine phosphatasesTarget therapy |
| spellingShingle | Chia-Hsueh Lin Ying-Chun Yeh Kuender D. Yang Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers Journal of the Formosan Medical Association Sialic acid (SA) Sialic acid-binding immunoglobulin-like lectins (Siglecs) SA-Siglec axis Src homology 2 tyrosine phosphatases Target therapy |
| title | Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers |
| title_full | Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers |
| title_fullStr | Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers |
| title_full_unstemmed | Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers |
| title_short | Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers |
| title_sort | functions and therapeutic targets of siglec mediated infections inflammations and cancers |
| topic | Sialic acid (SA) Sialic acid-binding immunoglobulin-like lectins (Siglecs) SA-Siglec axis Src homology 2 tyrosine phosphatases Target therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0929664619300968 |
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