Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers

Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers

Siglecs, sialic acid (SA)-binding immunoglobulin (Ig)-like lectins, belong to a family of Ig-like lectins. All Siglecs have at least two domains including an extracellular domain with variable (V) and constant (C)-set immunoglobulin (Ig) regions, and a transmembrane domain. Some of the Siglecs (Sigl...

Full description

Bibliographic Details
Main Authors:	Chia-Hsueh Lin, Ying-Chun Yeh, Kuender D. Yang
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	Journal of the Formosan Medical Association
Subjects:	Sialic acid (SA) Sialic acid-binding immunoglobulin-like lectins (Siglecs) SA-Siglec axis Src homology 2 tyrosine phosphatases Target therapy
Online Access:	http://www.sciencedirect.com/science/article/pii/S0929664619300968

Similar Items

Sialic Acid-Siglec-E Interactions During Pseudomonas aeruginosa Infection of Macrophages Interferes With Phagosome Maturation by Altering Intracellular Calcium Concentrations
by: Kaustuv Mukherjee, et al.
Published: (2020-02-01)

Siglecs as Therapeutic Targets in Cancer
by: Jackwee Lim, et al.
Published: (2021-11-01)

Current Status on Therapeutic Molecules Targeting Siglec Receptors
by: María Pia Lenza, et al.
Published: (2020-12-01)

Sialic Acid-Siglec Axis in Human Immune Regulation, Involvement in Autoimmunity and Cancer and Potential Therapeutic Treatments
by: Elena Gianchecchi, et al.
Published: (2021-05-01)

Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases
by: Jannis Wißfeld, et al.
Published: (2024-03-01)

Does SIGLEC8 localize to the subcellular compartment like the Alzheimer's disease protective CD33 splice variant?
by: Chirag Dhar
Published: (2023-04-01)

Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis
by: Chang-Shin Park, et al.
Published: (2011-06-01)

Sialylated Cervical Mucins Inhibit the Activation of Neutrophils to Form Neutrophil Extracellular Traps in Bovine in vitro Model
by: Kim F. Bornhöfft, et al.
Published: (2019-11-01)

Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer
by: John Daly, et al.
Published: (2019-05-01)

Expression of a Siglec-Fc Protein and Its Characterization
by: Kaijun Chi, et al.
Published: (2023-04-01)

Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway
by: Bingxin Zheng, et al.
Published: (2022-07-01)

Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
by: Przemyslaw Wielgat, et al.
Published: (2020-06-01)

Siglec Signaling in the Tumor Microenvironment
by: Eline J. H. van Houtum, et al.
Published: (2021-12-01)

Sequence variety in the CC’ loop of Siglec-8/9/3 determines the recognitions to sulfated oligosaccharides
by: Yucheng Wang, et al.
Published: (2023-01-01)

Hypersialylation in Cancer: Modulation of Inflammation and Therapeutic Opportunities
by: Emily Rodrigues, et al.
Published: (2018-06-01)

B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding
by: Sarah J. Meyer, et al.
Published: (2018-12-01)

Siglec-15: a potential regulator of osteoporosis, cancer, and infectious diseases
by: Takashi Angata
Published: (2020-01-01)

SIGLEC-5/14 Inhibits CD11b/CD18 Integrin Activation and Neutrophil-Mediated Tumor Cell Cytotoxicity
by: Panagiota Bouti, et al.
Published: (2023-12-01)

Bacterial sialoglycosidases in Virulence and Pathogenesis
by: Preethi Sudhakara, et al.
Published: (2019-03-01)

Control of Innate Immunity by Sialic Acids in the Nervous Tissue
by: Huan Liao, et al.
Published: (2020-07-01)

The Role of Sialic Acids in the Establishment of Infections by Pathogens, With Special Focus on Leishmania
by: Tainá Cavalcante, et al.
Published: (2021-05-01)

The therapeutic potential of sialylated Fc domains of human IgG
by: Richard J. Pleass
Published: (2021-01-01)

Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs
by: Takashi Angata
Published: (2018-12-01)

Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation
by: Yaw-Wen Hsu, et al.
Published: (2021-01-01)

Inhibitory Siglec-sialic acid interactions in balancing immunological activation and tolerance during viral infections
by: Pratima Saini, et al.
Published: (2022-12-01)

Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes
by: Dong Won Kim, et al.
Published: (2022-12-01)

Sialic Acid Mimetic Microglial Sialic Acid-Binding Immunoglobulin-like Lectin Agonism: Potential to Restore Retinal Homeostasis and Regain Visual Function in Age-Related Macular Degeneration
by: Michael J. Tolentino, et al.
Published: (2023-12-01)

Sialic Acid—Modified Nanoparticles—New Approaches in the Glioma Management—Perspective Review
by: Przemyslaw Wielgat, et al.
Published: (2021-07-01)

Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression
by: Kevin James Metcalf, et al.
Published: (2022-06-01)

Altered Cell Adhesion and Glycosylation Promote Cancer Immune Suppression and Metastasis
by: Heinz Läubli, et al.
Published: (2019-09-01)

Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells
by: Yun Cao, et al.
Published: (2023-10-01)

Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes
by: Mohammed Saqif Ahmad, et al.
Published: (2023-10-01)

Comparison of Siglec-1 protein networks and expression patterns in sperm and male reproductive tracts of mice, rats, and humans
by: Hazem Almhanna, et al.
Published: (2024-03-01)

Sialic Acids in the Immune Response during Sepsis
by: Yan-Cun Liu, et al.
Published: (2017-11-01)

Hypersialylation and multiple myeloma
by: Michael O’Dwyer, et al.
Published: (2024-02-01)

Sialic Acids and Their Influence on Human NK Cell Function
by: Philip Rosenstock, et al.
Published: (2021-01-01)

Characterization of Sialic Acid-Binding Immunoglobulin-Type Lectins in Fish Reveals Teleost-Specific Structures and Expression Patterns
by: Kim F. Bornhöfft, et al.
Published: (2020-03-01)

Interplay Between Sialic Acids, Siglec-E, and Neu1 Regulates MyD88- and TRIF-Dependent Pathways for TLR4-Activation During Leishmania donovani Infection
by: Joyshree Karmakar, et al.
Published: (2021-03-01)

Siglecs in Brain Function and Neurological Disorders
by: Shoib Sarwar Siddiqui, et al.
Published: (2019-09-01)

Molecular Recognition Insights of Sialic Acid Glycans by Distinct Receptors Unveiled by NMR and Molecular Modeling
by: Cátia Oliveira Soares, et al.
Published: (2021-11-01)