HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

In the present study, we hypothesized that hypoxia-inducible factor 1α (HIF-1α)-mediated mitophagy plays a protective role in ischemia/reperfusion (I/R)-induced acute kidney injury (AKI). Mitophagy was evaluated by measuring the changes of mitophagy flux, mitochondria DNA copy number, and the change...

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Bibliographic Details
Main Authors: Zong-Jie Fu, Zhi-Yu Wang, Lian Xu, Xiao-Hui Chen, Xiang-Xiao Li, Wei-Tang Liao, Hong-Kun Ma, Meng-Di Jiang, Ting-Ting Xu, Jing Xu, Yan Shen, Bei Song, Ping-Jin Gao, Wei-Qing Han, Wen Zhang
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Tubular cells
Hypoxia-inducible factor 1α
Bcl-2 19-kDa interacting protein 3
Mitophagy
Acute kidney injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720308764

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http://www.sciencedirect.com/science/article/pii/S2213231720308764

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