PSD-95 inhibitor Tat-NR2B9c (NA-1) protects the integrity of the blood-brain barrier after transient middle artery occlusion in rats by downregulating matrix metalloprotease-9 and upregulating endothelial nitric oxide synthase

PSD-95 inhibitor Tat-NR2B9c (NA-1) protects the integrity of the blood-brain barrier after transient middle artery occlusion in rats by downregulating matrix metalloprotease-9 and upregulating endothelial nitric oxide synthase

Background: Protection against ischemic stroke may be most effective when multiple components of the neurovascular unit are protected, yet current treatments target mainly neurons. Here we explored whether the PSD-95 inhibitor Tat-NR2B9c (NA-1) can protect not only neurons but also the blood-brain b...

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Bibliographic Details
Main Authors: Ye Xu, Lu Xu, Chunfei Xu, Meiqi Zhao, Tong Xu, Lingfan Xia, Yucong Wu, Yungang Cao, Zhao Han
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Brain Research Bulletin
Subjects:
Tat-NR2B9c (NA-1)
PSD-95
Middle cerebral artery occlusion
Blood-brain barrier
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923023002617

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http://www.sciencedirect.com/science/article/pii/S0361923023002617

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