Network hub-node prioritization of gene regulation with intra-network association

Network hub-node prioritization of gene regulation with intra-network association

Abstract Background To identify and prioritize the influential hub genes in a gene-set or biological pathway, most analyses rely on calculation of marginal effects or tests of statistical significance. These procedures may be inappropriate since hub nodes are common connection points and therefore m...

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Bibliographic Details
Main Authors: Hung-Ching Chang, Chiao-Pei Chu, Shu-Ju Lin, Chuhsing Kate Hsiao
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Bioinformatics
Subjects:
Direction regularization
Intra-network
Neighbor correlation
Pathway activity score
Topology measure
Online Access:http://link.springer.com/article/10.1186/s12859-020-3444-7

Internet

http://link.springer.com/article/10.1186/s12859-020-3444-7

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