Identification of Small Molecules that Modulate Mutant p53 Condensation

Identification of Small Molecules that Modulate Mutant p53 Condensation

Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions through a condensate-like state. We show condensate-...

Full description

Bibliographic Details
Main Authors: Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Biochemistry Methods
Medical Biochemistry
Structural Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220307094

Internet

http://www.sciencedirect.com/science/article/pii/S2589004220307094

Similar Items