Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

Summary: Pancreatic ductal adenocarcinoma (PDAC) remains one of the human cancers with the poorest prognosis. Interestingly, we found that mitochondrial respiration in primary human PDAC cells depends mainly on the fatty acid oxidation (FAO) to meet basic energy requirements. Therefore, we treated P...

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Bibliographic Details
Main Authors: Gabriela Reyes-Castellanos, Nadine Abdel Hadi, Scarlett Gallardo-Arriaga, Rawand Masoud, Julie Garcia, Sophie Lac, Abdessamad El Kaoutari, Tristan Gicquel, Mélanie Planque, Sarah-Maria Fendt, Laetitia Karine Linares, Odile Gayet, Fabienne Guillaumond, Nelson Dusetti, Juan Iovanna, Alice Carrier
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
Cancer systems biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009768

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http://www.sciencedirect.com/science/article/pii/S2589004223009768

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