A Novel System for the Detection of Spontaneous Abortion-Causing Aneuploidy and Its Erroneous Chromosome Origins through the Combination of Low-Pass Copy Number Variation Sequencing and NGS-Based STR Tests

A Novel System for the Detection of Spontaneous Abortion-Causing Aneuploidy and Its Erroneous Chromosome Origins through the Combination of Low-Pass Copy Number Variation Sequencing and NGS-Based STR Tests

During the period of 2018–2020, we first combined reported low-pass whole genome sequencing and NGS-based STR tests for miscarriage samples analysis. Compared with G-banding karyotyping, the system increased the detection rate of chromosomal abnormalities in miscarriage samples to 56.4% in 500 unexp...

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Bibliographic Details
Main Authors: Caixia Lei, Kai Liao, Yuwei Zhao, Zhoukai Long, Saijuan Zhu, Junping Wu, Min Xiao, Jing Zhou, Shuo Zhang, Lianbin Li, Yijian Zhu, Daru Lu, Jingmin Yang, Xiaoxi Sun
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Journal of Clinical Medicine
Subjects:
low-pass copy number variation sequencing
NGS-based STR test
miscarriage samples
aneuploidy
chromosome error origins
Online Access:https://www.mdpi.com/2077-0383/12/5/1809

Internet

https://www.mdpi.com/2077-0383/12/5/1809

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