MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy

MT1‐MMP‐Activated Liposomes to Improve Tumor Blood Perfusion and Drug Delivery for Enhanced Pancreatic Cancer Therapy

Abstract Promoting tumor angiogenesis effectively and specifically to resolve tumor‐associated hypoperfusion holds promise for improving pancreatic cancer therapy. Herein, a doxorubicin (DOX) loaded smart liposome, MC‐T‐DOX, is constructed, that carries appropriately low‐density cilengitide, an αvβ3...

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Bibliographic Details
Main Authors: Yan Wei, Sha Song, Nianxiu Duan, Feng Wang, Yuxi Wang, Yiwei Yang, Chengyuan Peng, Junjun Li, Di Nie, Xinxin Zhang, Shiyan Guo, Chunliu Zhu, Miaorong Yu, Yong Gan
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Advanced Science
Subjects:
membrane type 1‐matrix metalloproteinase‐activated cilengitide
pancreatic cancer
smart liposomes
vascular promotion
Online Access:https://doi.org/10.1002/advs.201902746

Internet

https://doi.org/10.1002/advs.201902746

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