On your marks, get SET(D1A): the race to protect stalled replication forks

On your marks, get SET(D1A): the race to protect stalled replication forks

We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA compleme...

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Bibliographic Details
Main Authors: Shabana Begum, Amalia Goula, Rachel Bayley, Martin R. Higgs
Format: Article
Language:English
Published: Taylor & Francis Group 2018-11-01
Series:Molecular & Cellular Oncology
Subjects:
genome stability
setd1a
fancd2
replication stress
chemoresistance
chd4
Online Access:http://dx.doi.org/10.1080/23723556.2018.1511209

Internet

http://dx.doi.org/10.1080/23723556.2018.1511209

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