On your marks, get SET(D1A): the race to protect stalled replication forks
We recently identified that methylation of lysine 4 of histone H3 (H3K4) by SETD1A (SET domain containing 1A) maintains genome stability by protecting newly-replicated DNA from degradation. Mechanistically, SETD1A-dependent histone methylation regulates nucleosome mobilisation by FANCD2 (FA compleme...
Main Authors: | Shabana Begum, Amalia Goula, Rachel Bayley, Martin R. Higgs |
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Format: | Article |
Language: | English |
Published: |
Taylor & Francis Group
2018-11-01
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Series: | Molecular & Cellular Oncology |
Subjects: | |
Online Access: | http://dx.doi.org/10.1080/23723556.2018.1511209 |
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