A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors

A Hot-spot of In-frame Duplications Activates the Oncoprotein AKT1 in Juvenile Granulosa Cell Tumors

Background: Ovarian granulosa cell tumors are the most common sex-cord stromal tumors and have juvenile (JGCTs) and adult forms. In a previous study we reported the occurrence of activating somatic mutations of Gαs, which transduces mitogenic signals, in 30% of the analyzed JGCTs. Methods: We have s...

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Bibliographic Details
Main Authors: Laurianne Bessière, Anne-Laure Todeschini, Aurélie Auguste, Sabine Sarnacki, Delphine Flatters, Bérangère Legois, Charles Sultan, Nicolas Kalfa, Louise Galmiche, Reiner A. Veitia
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:EBioMedicine
Subjects:
AKT1
Ovary
Juvenile granulosa cell tumor
Activating mutation
Oncogene
Oncoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000651

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http://www.sciencedirect.com/science/article/pii/S2352396415000651

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