Identification of Escherichia coli β-glucuronidase inhibitors from Polygonum cuspidatum Siebold & Zucc.

Identification of Escherichia coli β-glucuronidase inhibitors from Polygonum cuspidatum Siebold & Zucc.

Abstract Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic circulation- triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced enteropathy and improve treatment outcomes. We evaluated the inhibitory effect of Polygonum cuspidatum Si...

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Bibliographic Details
Main Authors: Jing-Xin Li, Yu Wang, Ying Hao, Xiao-Kui Huo, Cheng-Peng Sun, Xiao-Xia Zhao, Jin-Cheng Wang, Jian-Bin Zhang, Jing Ning, Xiang-Ge Tian, Chao Wang, Wen-Yu Zhao, Xia Lv, Ya-Chen Li, Xiao-Chi Ma
Format: Article
Language:English
Published: Universidade de São Paulo 2023-01-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
β-glucuronidase
Polygonum cuspidatum Siebold & Zucc.
Trans-resveratrol 4’-O-β-D-glucopyranoside
(-)-Epicatechin gallate
Inhibitory mechanism
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100307&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100307&tlng=en

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