Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Multiplex quantitative analysis of stroma-mediated cancer cell invasion, matrix remodeling, and drug response in a 3D co-culture model of pancreatic tumor spheroids and stellate cells

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a stroma-rich carcinoma, and pancreatic stellate cells (PSCs) are a major component of this dense stroma. PSCs play significant roles in metastatic progression and chemoresistance through cross-talk with cancer cells. Preclinical in vitr...

Full description

Bibliographic Details
Main Authors: Hyun Ju Hwang, Min-Suk Oh, Dong Woo Lee, Hyo-Jeong Kuh
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Tumor spheroids
Pancreatic stellate cell
Tumor microenvironment
Matrix remodeling
3D co-culture
Cancer invasion
Online Access:http://link.springer.com/article/10.1186/s13046-019-1225-9

Internet

http://link.springer.com/article/10.1186/s13046-019-1225-9

Similar Items