Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.

The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To bet...

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Main Authors: Yidan Xue, Theodosia Georgakopoulou, Anne-Eva van der Wijk, Tamás I Józsa, Ed van Bavel, Stephen J Payne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010166
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author Yidan Xue
Theodosia Georgakopoulou
Anne-Eva van der Wijk
Tamás I Józsa
Ed van Bavel
Stephen J Payne
author_facet Yidan Xue
Theodosia Georgakopoulou
Anne-Eva van der Wijk
Tamás I Józsa
Ed van Bavel
Stephen J Payne
author_sort Yidan Xue
collection DOAJ
description The microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both in vivo experiments and in silico simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 μm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transport of microspheres of the same size and the oxygen transport was simulated using a Green's function method. The locations of microspheres and hypoxic regions were segmented, and two novel distance analyses were implemented to study their spatial correlation. The distant hypoxic regions were found to be present in both experiments and simulations, and mainly due to the hypoperfusion in the region downstream of the occlusion site. Furthermore, a reasonable agreement for the spatial correlation between hypoxic regions and occlusion sites is shown between experiments and simulations, which indicates the good applicability of in silico models in understanding the response of cerebral blood flow and oxygen transport to microemboli.
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spelling doaj.art-a23102fbefdd493c82a72e16d9f467152022-12-22T03:07:34ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582022-08-01188e101016610.1371/journal.pcbi.1010166Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.Yidan XueTheodosia GeorgakopoulouAnne-Eva van der WijkTamás I JózsaEd van BavelStephen J PayneThe microvasculature plays a key role in oxygen transport in the mammalian brain. Despite the close coupling between cerebral vascular geometry and local oxygen demand, recent experiments have reported that microvascular occlusions can lead to unexpected distant tissue hypoxia and infarction. To better understand the spatial correlation between the hypoxic regions and the occlusion sites, we used both in vivo experiments and in silico simulations to investigate the effects of occlusions in cerebral penetrating arteriole trees on tissue hypoxia. In a rat model of microembolisation, 25 μm microspheres were injected through the carotid artery to occlude penetrating arterioles. In representative models of human cortical columns, the penetrating arterioles were occluded by simulating the transport of microspheres of the same size and the oxygen transport was simulated using a Green's function method. The locations of microspheres and hypoxic regions were segmented, and two novel distance analyses were implemented to study their spatial correlation. The distant hypoxic regions were found to be present in both experiments and simulations, and mainly due to the hypoperfusion in the region downstream of the occlusion site. Furthermore, a reasonable agreement for the spatial correlation between hypoxic regions and occlusion sites is shown between experiments and simulations, which indicates the good applicability of in silico models in understanding the response of cerebral blood flow and oxygen transport to microemboli.https://doi.org/10.1371/journal.pcbi.1010166
spellingShingle Yidan Xue
Theodosia Georgakopoulou
Anne-Eva van der Wijk
Tamás I Józsa
Ed van Bavel
Stephen J Payne
Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
PLoS Computational Biology
title Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
title_full Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
title_fullStr Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
title_full_unstemmed Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
title_short Quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees.
title_sort quantification of hypoxic regions distant from occlusions in cerebral penetrating arteriole trees
url https://doi.org/10.1371/journal.pcbi.1010166
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