A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode

A potent synthetic nanobody with broad-spectrum activity neutralizes SARS-CoV-2 virus and the Omicron variant BA.1 through a unique binding mode

Abstract The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the neutralizing antibodies to date. Thus, it is essential to develop neutralizing antibodies with broad-spectrum activit...

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Bibliographic Details
Main Authors: Dongping Zhao, Liqin Liu, Xinlin Liu, Jinlei Zhang, Yuqing Yin, Linli Luan, Dingwen Jiang, Xiong Yang, Lei Li, Hualong Xiong, Dongming Xing, Qingbing Zheng, Ningshao Xia, Yuyong Tao, Shaowei Li, Haiming Huang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Nanobiotechnology
Subjects:
SARS-CoV-2
Neutralizing antibody
Synthetic nanobody
Broad-spectrum
Omicron
Cryo-EM
Online Access:https://doi.org/10.1186/s12951-022-01619-y

Internet

https://doi.org/10.1186/s12951-022-01619-y

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