The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats

The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as a consecutive administration (12.5 mg/kg/day)...

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Bibliographic Details
Main Authors: Saki Shiga, Takuji Machida, Takumi Yanada, Maiko Machida, Masahiko Hirafuji, Kenji Iizuka
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300189