A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

Several metabolites have been shown to have independent and at times unexpected biological effects outside of their metabolic pathways. These include succinate, lactate, fumarate, and 2-hydroxyglutarate. 2-Hydroxybutyrate (2HB) is a byproduct of endogenous cysteine synthesis, produced during periods...

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Bibliographic Details
Main Authors: Brennan J Wadsworth, Marina Leiwe, Eleanor A Minogue, Pedro P Cunha, Viktor Engman, Carolin Brombach, Christos Asvestis, Shiv K Sah-Teli, Emilia Marklund, Peppi Koivunen, Jorge L Ruas, Helene Rundqvist, Johanna T Lanner, Randall S Johnson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-09-01
Series:eLife
Subjects:
Exercise
muscle fiber
metabolite
Online Access:https://elifesciences.org/articles/92707

Internet

https://elifesciences.org/articles/92707

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