Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus

Mitochondria-Targeted Human Catalase in the Mouse Longevity MCAT Model Mitigates Head-Tilt Bedrest-Induced Neuro-Inflammation in the Hippocampus

Microgravity (modeled by head-tilt bedrest and hind-limb unloading), experienced during prolonged spaceflight, results in neurological consequences, central nervous system (CNS) dysfunction, and potentially impairment during the performance of critical tasks. Similar pathologies are observed in bedr...

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Bibliographic Details
Main Authors: Linda Rubinstein, Frederico Kiffer, Stephanie Puukila, Moniece G. Lowe, Brie Goo, Amalia Luthens, Ann-Sofie Schreurs, Samantha M. Torres, Sonette Steczina, Candice G. T. Tahimic, Antiño R. Allen
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
microgravity
CNS
hind limb unloading
microglia
ROS
MCAT
Online Access:https://www.mdpi.com/2075-1729/12/11/1838

Internet

https://www.mdpi.com/2075-1729/12/11/1838

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