Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease

Background: Earlier studies reported alterations of the kynurenine (KYN) pathway of tryptophan (TRP) metabolism in Parkinson’s disease (PD). The first rate-limiting enzymes indoleamine 2,3-dioxygenase (IDO) and tryptophan dioxygenase were observed upregulated, resulting elevated KYN/TRP ratios in th...

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Bibliographic Details
Main Authors: Nóra Török, Rita Maszlag-Török, Kinga Molnár, Zoltán Szolnoki, Ferenc Somogyvári, Krisztina Boda, Masaru Tanaka, Péter Klivényi, László Vécsei
Format: Article
Language:English
Published: IMR Press 2022-09-01
Series:Frontiers in Bioscience-Landmark
Subjects:
kynurenine
tryptophan
indoleamine 2
3-dioxygenase
ido
parkinson's diseases
single nucleotide polymorphisms
biomarker
age
onset
Online Access:https://www.imrpress.com/journal/FBL/27/9/10.31083/j.fbl2709265

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https://www.imrpress.com/journal/FBL/27/9/10.31083/j.fbl2709265

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