Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis

Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis

Abstract Background The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure remains unclear. Results Here we discovered that Piezo1, a mechanosensitiv...

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Bibliographic Details
Main Authors: Xiaoqiang Yang, Honghui Zeng, Le Wang, Siweier Luo, Yiming Zhou
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cell & Bioscience
Subjects:
Piezo1 ion channel
Renin
Calcium signaling
Juxtaglomerular cell
Mechanical stress
Blood pressure homeostasis
Online Access:https://doi.org/10.1186/s13578-022-00931-2

Internet

https://doi.org/10.1186/s13578-022-00931-2

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