Activation of Piezo1 downregulates renin in juxtaglomerular cells and contributes to blood pressure homeostasis
Abstract Background The synthesis and secretion of renin in juxtaglomerular (JG) cells are closely regulated by the blood pressure. To date, however, the molecular identity through which JG cells respond to the blood pressure remains unclear. Results Here we discovered that Piezo1, a mechanosensitiv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-12-01
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| Series: | Cell & Bioscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13578-022-00931-2 |