Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Novel kinetoplastid-specific cAMP binding proteins identified by RNAi screening for cAMP resistance in Trypanosoma brucei

Cyclic AMP signalling in trypanosomes differs from most eukaryotes due to absence of known cAMP effectors and cAMP independence of PKA. We have previously identified four genes from a genome-wide RNAi screen for resistance to the cAMP phosphodiesterase (PDE) inhibitor NPD-001. The genes were named c...

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Bibliographic Details
Main Authors: Sabine Bachmaier, Matthew K. Gould, Eleni Polatoglou, Radoslaw Omelianczyk, Ana E. Brennand, Maha A. Aloraini, Jane C. Munday, David Horn, Michael Boshart, Harry P. de Koning
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma brucei
cAMP
CARP
flagellum
adenylate cyclase
RNAi screening
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1204707/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1204707/full

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