4308 DEEP-PRIMED IL-15 SUPERAGONIST IMPROVES ANTIVIRAL EFFICACY OF HIV-SPECIFIC CD8+ T-CELLS IN HUMANIZED MOUSE MODEL

4308 DEEP-PRIMED IL-15 SUPERAGONIST IMPROVES ANTIVIRAL EFFICACY OF HIV-SPECIFIC CD8+ T-CELLS IN HUMANIZED MOUSE MODEL

OBJECTIVES/GOALS: HIV-specific CD8+ T-cells play a critical role in partially controlling viral replication in infected-individuals, but ultimately fail to eliminate infection. Enhancing these T-cell responses through lymphocyte engineering approaches has the potential as a novel therapy capable of...

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Bibliographic Details
Main Authors: Chase Daniel McCann, Elizabeth Zale, Adam Ward, Thomas Dilling, Ali Danesh, Eva Stevenson, Talia Mota, Austin Boesch, Thomas Andresen, Darrell Irvine, R. Brad Jones
Format: Article
Language:English
Published: Cambridge University Press 2020-06-01
Series:Journal of Clinical and Translational Science
Online Access:https://www.cambridge.org/core/product/identifier/S205986612000059X/type/journal_article

Internet

https://www.cambridge.org/core/product/identifier/S205986612000059X/type/journal_article

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