Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

Targeting Emerging RNA Viruses by Engineered Human Superantibody to Hepatitis C Virus RNA-Dependent RNA Polymerase

RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein. Therefore, the RdRp is an attractive target for a broadly effective therapeutic agent against RNA viruses. In this stu...

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Bibliographic Details
Main Authors: Kittirat Glab-ampai, Kanasap Kaewchim, Techit Thavorasak, Thanatsaran Saenlom, Watayagorn Thepsawat, Kodchakorn Mahasongkram, Kanyarat Thueng-In, Nitat Sookrung, Wanpen Chaicumpa, Monrat Chulanetra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Microbiology
Subjects:
RNA viruses
RNA-dependent RNA polymerase
phage display
human single-chain antibody variable fragment
superantibody (cell penetrating antibody)
computerized simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.926929/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.926929/full

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