Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

Epoxide hydrolysis as a model system for understanding flux through a branched reaction scheme

The epoxide hydrolase StEH1 catalyzes the hydrolysis of trans-methylstyrene oxide to 1-phenylpropane-1,2-diol. The (S,S)-epoxide is exclusively transformed into the (1R,2S)-diol, while hydrolysis of the (R,R)-epoxide results in a mixture of product enantiomers. In order to understand the differences...

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Bibliographic Details
Main Authors: Åsa Janfalk Carlsson, Paul Bauer, Doreen Dobritzsch, Shina C. L. Kamerlin, Mikael Widersten
Format: Article
Language:English
Published: International Union of Crystallography 2018-05-01
Series:IUCrJ
Subjects:
epoxide hydrolase
stereoselectivity
empirical valence-bond simulations
biocatalysis
reaction flux
trans-methylstyrene oxide
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252518003573

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http://scripts.iucr.org/cgi-bin/paper?S2052252518003573

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