Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies

Assessment of the practical impact of adjusting beta-lactam dosages based on therapeutic drug monitoring in critically ill adult patients: a systematic review and meta-analysis of randomized clinical trials and observational studies

Abstract An estimated 70% of critically ill patients receive antibiotics, most frequently beta-lactams. The pharmacokinetic properties of these substances in this patient population are poorly predictable. Therapeutic drug monitoring (TDM) is helpful in making personalized decisions in this field, b...

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Bibliographic Details
Main Authors: Eszter Gulyás, István László Horváth, Marie Anne Engh, Stefania Bunduc, Fanni Dembrovszky, Péter Fehérvári, András Bánvölgyi, Dezső Csupor, Péter Hegyi, Gellért Balázs Karvaly
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Beta-lactam
Therapeutic drug monitoring
Meta-analysis
ICU
Critically ill
Online Access:https://doi.org/10.1038/s41598-024-58200-w

Internet

https://doi.org/10.1038/s41598-024-58200-w

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