Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression

Modeling Glanzmann thrombasthenia using patient specific iPSCs and restoring platelet aggregation function by CD41 overexpression

Glanzmann thrombasthenia (GT) is a rare monogenic hemorrhagic disorder involving aggregation defect of non-nuclear platelets. In this study we generated induced pluripotent stem cells (iPSCs) from skin fibroblasts of a GT patient with complex heterogeneous mutations of ITGA2B gene. GT-iPSCs could be...

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Bibliographic Details
Main Authors: Liang Hu, Lili Du, Yan Zhao, Wen Li, Qi Ouyang, Di Zhou, Guangxiu Lu, Ge Lin
Format: Article
Language:English
Published: Elsevier 2017-04-01
Series:Stem Cell Research
Subjects:
Glanzmann thrombasthenia
Induced pluripotent stem cells
Platelet
CD41
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506117300168

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http://www.sciencedirect.com/science/article/pii/S1873506117300168

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