Dimethyl fumarate modulates the regulatory T cell response in the mesenteric lymph nodes of mice with experimental autoimmune encephalomyelitis

Dimethyl fumarate modulates the regulatory T cell response in the mesenteric lymph nodes of mice with experimental autoimmune encephalomyelitis

Dimethyl fumarate (DMF, Tecfidera) is an oral drug utilized to treat relapsing-remitting multiple sclerosis (MS). DMF treatment reduces disease activity in MS. Gastrointestinal discomfort is a common adverse effect of the treatment with DMF. This study aimed to investigate the effect of DMF administ...

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Bibliographic Details
Main Authors: Amanda D. R. Lima, Breno B. Ferrari, Fernando Pradella, Rodrigo M. Carvalho, Sandra L. S. Rivero, Raphael P. S. Quintiliano, Matheus A. Souza, Natália S. Brunetti, Ana M. Marques, Irene P. Santos, Alessandro S. Farias, Elaine C. Oliveira, Leonilda M. B. Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Immunology
Subjects:
dimethyl fumarate
experimental autoimmune encephalomyelitis
type 1 regulatory T cells
anti-inflammatory cytokines
gut draining lymph nodes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391949/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1391949/full

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