Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors

Spatial genomics reveals a high number and specific location of B cells in the pancreatic ductal adenocarcinoma microenvironment of long-term survivors

Background and aimOnly 10% of pancreatic ductal adenocarcinoma (PDAC) patients survive longer than five years. Factors underlining long-term survivorship in PDAC are not well understood. Therefore, we aimed to identify the key players in the tumor immune microenvironment (TIME) associated with long-...

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Bibliographic Details
Main Authors: Hosein M. Aziz, Lawlaw Saida, Willem de Koning, Andrew P. Stubbs, Yunlei Li, Kostandinos Sideras, Elena Palacios, Jaime Feliu, Marta Mendiola, Casper H. J. van Eijck, Dana A. M. Mustafa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
pancreatic ductal adenocarcinoma
long-term survival
B cells
tumor immune microenvironment
gene expression
spatial genomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.995715/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.995715/full

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