Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.

Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.

The proteasome cleaves intracellular proteins into peptides. Earlier studies found that treatment of human embryonic kidney 293T (HEK293T) cells with epoxomicin (an irreversible proteasome inhibitor) generally caused a decrease in levels of intracellular peptides. However, bortezomib (an antitumor d...

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Bibliographic Details
Main Authors: Sayani Dasgupta, Leandro M Castro, Russell Dulman, Ciyu Yang, Marion Schmidt, Emer S Ferro, Lloyd D Fricker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4117522?pdf=render

Internet

http://europepmc.org/articles/PMC4117522?pdf=render

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