Direct transformation of lung microenvironment by interferon-α treatment counteracts growth of lung metastasis of hepatocellular carcinoma.

Direct transformation of lung microenvironment by interferon-α treatment counteracts growth of lung metastasis of hepatocellular carcinoma.

BACKGROUND: Interferon (IFN)-α is effective in inhibiting tumor growth and metastasis of hepatocellular carcinoma (HCC). However, the biologic mechanisms of IFN-α treatment in lung metastasis are not yet clear. METHODS: The effect of IFN-α treatment was studied by using an orthotopic xenograft model...

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Bibliographic Details
Main Authors: Peng-Yuan Zhuang, Jun Shen, Xiao-Dong Zhu, Ju-Bo Zhang, Zhao-You Tang, Lun-Xiu Qin, Hui-Chuan Sun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3601095?pdf=render

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http://europepmc.org/articles/PMC3601095?pdf=render

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