Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes

Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes

T-cell receptor stimulation induces the convergence of multivesicular bodies towards the microtubule-organizing centre (MTOC) and the polarization of the MTOC to the immune synapse (IS). These events lead to exosome secretion at the IS. We describe here that upon IS formation centrosomal area F-acti...

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Bibliographic Details
Main Authors: Ana Bello-Gamboa, Marta Velasco, Solange Moreno, Gonzalo Herranz, Roxana Ilie, Silvia Huetos, Sergio Dávila, Alicia Sánchez, Jorge Bernardino De La Serna, Víctor Calvo, Manuel Izquierdo
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Journal of Extracellular Vesicles
Subjects:
t lymphocytes
immune synapse
actin cytoskeleton
protein kinase c δ
centrosome
multivesicular bodies
fmnl1
paxillin
Online Access:http://dx.doi.org/10.1080/20013078.2020.1759926

Internet

http://dx.doi.org/10.1080/20013078.2020.1759926

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