Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease
Multimodal PET-fMRI imaging of Alzheimer’s disease patients and healthy controls suggests that microglia activation in the posterior cingulate cortex is associated with increased brain activity in Alzheimer’s disease, and independent of amyloid accumulation.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03761-7 |
| _version_ | 1811320779141283840 |
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| author | Nádia Canário Lília Jorge Ricardo Martins Isabel Santana Miguel Castelo-Branco |
| author_facet | Nádia Canário Lília Jorge Ricardo Martins Isabel Santana Miguel Castelo-Branco |
| author_sort | Nádia Canário |
| collection | DOAJ |
| description | Multimodal PET-fMRI imaging of Alzheimer’s disease patients and healthy controls suggests that microglia activation in the posterior cingulate cortex is associated with increased brain activity in Alzheimer’s disease, and independent of amyloid accumulation. |
| first_indexed | 2024-04-13T13:05:25Z |
| format | Article |
| id | doaj.art-a2557a45f8af4333a145fa03c512b6e6 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T13:05:25Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-a2557a45f8af4333a145fa03c512b6e62022-12-22T02:45:47ZengNature PortfolioCommunications Biology2399-36422022-08-01511710.1038/s42003-022-03761-7Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s diseaseNádia Canário0Lília Jorge1Ricardo Martins2Isabel Santana3Miguel Castelo-Branco4Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of CoimbraCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of CoimbraCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of CoimbraFaculty of Medicine, University of CoimbraCoimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of CoimbraMultimodal PET-fMRI imaging of Alzheimer’s disease patients and healthy controls suggests that microglia activation in the posterior cingulate cortex is associated with increased brain activity in Alzheimer’s disease, and independent of amyloid accumulation.https://doi.org/10.1038/s42003-022-03761-7 |
| spellingShingle | Nádia Canário Lília Jorge Ricardo Martins Isabel Santana Miguel Castelo-Branco Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease Communications Biology |
| title | Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease |
| title_full | Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease |
| title_fullStr | Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease |
| title_full_unstemmed | Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease |
| title_short | Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease |
| title_sort | dual pet fmri reveals a link between neuroinflammation amyloid binding and compensatory task related brain activity in alzheimer s disease |
| url | https://doi.org/10.1038/s42003-022-03761-7 |
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