The human inactive X chromosome modulates expression of the active X chromosome

The human inactive X chromosome modulates expression of the active X chromosome

Summary: The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling revealed modular Xi and Xa transcriptomes and significant Xi...

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Bibliographic Details
Main Authors: Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Format: Article
Language:English
Published: Elsevier 2023-02-01
Series:Cell Genomics
Subjects:
sex chromosomes
X chromosome inactivation
gene expression
sex differences
aneuploidy
turner syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X23000150

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http://www.sciencedirect.com/science/article/pii/S2666979X23000150

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