Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia

Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia

Abstract Background SPG11-linked hereditary spastic paraplegia is characterized by multisystem neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive spasticity and weakness. Severe cognitive symptoms are present in the majority of SPG11 patients, but a systematic...

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Bibliographic Details
Main Authors: Kathrin S. Utz, Zacharias Kohl, Dominique Cornelius Marterstock, Arnd Doerfler, Jürgen Winkler, Manuel Schmidt, Martin Regensburger
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Orphanet Journal of Rare Diseases
Subjects:
SPG11
Verbal fluency
Brain morphometry
Spastic paraplegia
Neuropsychology
Online Access:https://doi.org/10.1186/s13023-022-02451-1

Internet

https://doi.org/10.1186/s13023-022-02451-1

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