NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion

NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion

Activation of the inflammatory transcription factor NF-κB in tumor-associated macrophages (TAMs) is assumed to contribute to tumor promotion. However, whether and how NF-κB drives the antitumor macrophages to become pro-tumorigenic have not been determined in any cancer type yet. Similarly, how TAMs...

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Bibliographic Details
Main Authors: Liwen Li, Lei Han, Fan Sun, Jingjiao Zhou, Kim C. Ohaegbulam, Xudong Tang, Xingxing Zang, Kris A. Steinbrecher, Zhaoxia Qu, Gutian Xiao
Format: Article
Language:English
Published: Taylor & Francis Group 2018-06-01
Series:OncoImmunology
Subjects:
b7x/b7-h4/b7s1
immune checkpoint
il-10
lung cancer
nf-κb
rela/p65
tumor-associated macrophage
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1435250

Internet

http://dx.doi.org/10.1080/2162402X.2018.1435250

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