Three Related Enzymes in <named-content content-type="genus-species">Candida albicans</named-content> Achieve Arginine- and Agmatine-Dependent Metabolism That Is Essential for Growth and Fungal Virulence

ABSTRACT Amino acid metabolism is crucial for fungal growth and development. Ureohydrolases produce amines when acting on l-arginine, agmatine, and guanidinobutyrate (GB), and these enzymes generate ornithine (by arginase), putrescine (by agmatinase), or GABA (by 4-guanidinobutyrase or GBase). Candi...

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Bibliographic Details
Main Authors: Katja Schaefer, Jeanette Wagener, Ryan M. Ames, Stella Christou, Donna M. MacCallum, Steven Bates, Neil A. R. Gow
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mBio.01845-20