Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer’s disease (AD). Given this, an attractive IDE-centric strategy for the development of therapeutics for AD is to boost IDE’s activity for the clearance...

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Bibliographic Details
Main Authors: Qiuchen Zheng, Micheal T. Kebede, Bethany Lee, Claire A. Krasinski, Saadman Islam, Liliana A. Wurfl, Merc M. Kemeh, Valerie A. Ivancic, Charles E. Jakobsche, Donald E. Spratt, Noel D. Lazo
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
polyphenols
resveratrol
epigallocatechin-3-gallate
insulin-degrading enzyme
Online Access:https://www.mdpi.com/2076-3921/10/9/1342

Internet

https://www.mdpi.com/2076-3921/10/9/1342

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