Quantitative prediction of integrase inhibitor resistance from genotype through consensus linear regression modeling

Quantitative prediction of integrase inhibitor resistance from genotype through consensus linear regression modeling

<p>Abstract</p> <p>Background</p> <p>Integrase inhibitors (INI) form a new drug class in the treatment of HIV-1 patients. We developed a linear regression modeling approach to make a quantitative raltegravir (RAL) resistance phenotype prediction, as Fold Change in IC50...

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Bibliografske podrobnosti
Main Authors: Van der Borght Koen, Verheyen Ann, Feyaerts Maxim, Van Wesenbeeck Liesbeth, Verlinden Yvan, Van Craenenbroeck Elke, van Vlijmen Herman
Format: Article
Jezik:English
Izdano: BMC 2013-01-01
Serija:Virology Journal
Teme:
Consensus model
Genetic algorithm
Integrase
Linear regression
Raltegravir
Resistance
Online dostop:http://www.virologyj.com/content/10/1/8

Internet

http://www.virologyj.com/content/10/1/8

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